De quervain s thyroiditis pathophysiology

de Quervain's thyroiditis

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Last updated: April 27, Summary Subacute thyroiditis refers to a transient patchy inflammation of the thyroid gland that is associated either with granuloma formation subacute granulomatous thyroiditis or lymphocytic infiltration subacute lymphocytic thyroiditis. While subacute granulomatous thyroiditis usually occurs after a viral upper respiratory tract infectionsubacute lymphocytic thyroiditis occurs either during the postpartum periodin association with other autoimmune diseases, or as a side effect of certain drugs.

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Both forms of subacute thyroiditis are more common among women and are characterized by a triphasic clinical course that classically transitions from hyperthyroidism to hypothyroidismbefore returning to a euthyroid phase.

During the thyrotoxic phase, patients usually complain of fevermalaiseand goiterwhich is tender in subacute granulomatous thyroiditis and painless in subacute lymphocytic thyroiditis.

Diagnosis is confirmed by a combination of raised ESR and decreased iodine uptake in a radioiodine uptake study. During the thyrotoxic phase, beta blockers may be used to control the symptoms of thyrotoxicosisand NSAIDs may be used to control pain among patients with subacute granulomatous thyroiditis.

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Small doses of levothyroxine may be considered during the hypothyroid phase.

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